PCa - Hormonal Therapy Educational Sandbox

PCa - Hormonal Therapy (ADT Decision Tool)

Urological Education Disclaimer

This suite is a Deterministic Educational Sandbox for demonstration and training. It is NOT a clinical diagnostic tool and should NOT be used for actual patient treatment. Clinical decisions must be made by qualified medical professionals based on individualized assessment. Not for Clinical Use.

PCa - Hormonal Therapy

Educational Sandbox

Edge AI - Client side processing only

Created by Dr. Sharad Maheshwari

imagingsimplified@gmail.com

Clinical Parameters

System ready for
analysis

ADT Pharmacology & Dosing

Comparative Analysis & Standard Depot Intervals

Dimension Localized Focus Metastatic Focus
Clinical Intent Curative intensification (Adjuvant to RT) Lifelong suppression / Disease control
Duration Cycle Defined (6m, 18m, 36m) Lifelong / Indefinite
Flare Profile Surge usually low clinical impact Mandatory Anti-Androgen Shield
Common Dosages

1-Month Cycle

Leuprolide 7.5mg (SC)
Goserelin 3.6mg (IM)

3-Month Cycle

Leuprolide 22.5mg (SC)
Goserelin 10.8mg (IM)

6-Month Cycle

Leuprolide 45mg (SC)

Patient Counselling

01

Managing Flare

Explain the 1-week testosterone surge. Reassure that initial bone pain increase or urinary hesitancy is a temporary effect managed via anti-androgens.

02

Metabolic Balance

Counsel on diet and physical activity. Muscle loss and fat redistribution are primary side effects. Monitor BP and Glucose regularly.

03

Bone Preservation

Calcium (1200mg) and Vitamin D (800-1000IU) supplementation. Weight-bearing exercise is critical to mitigate bone loss.

Monitoring Strategy

Baseline DEXA Scan
Serial PSA + Testosterone
HbA1c / Lipid Panel (q6m)

"Castration is defined as Serum Testosterone <50 ng/dL. Baseline monitoring and cardiovascular risk assessment are key for long-term ADT survivorship."

Foundational References

NCCN Guidelines (v4.2024) Standard of care for curative course length and metastatic ADT backbone management.
EAU Guidelines: Prostate Cancer (2024) Evidence-based treatement pathways for castration protocols and flare protection.
HERO Trial Data (NEJM 2020) Clinical data comparing oral vs. injectable ADT and cardiovascular safety profiles.
WHO Model List of Essential Medicines Pharmacological equivalents for Goserelin/Leuprorelin in global health settings.

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